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Drugs that have been implicated in the causation of LPP include captopril, cinnarizine, ramipril, simvastatin, PUVA, and antituberculous medications. Adapted from Ref. Malignancies are a major cause of exfoliative dermatitis. 583-587. The most commonly used steroids were methylprednisolone, prednisolone and dexamethasone. Topical treatment. b. Atopic dermatitis. These measures include bed rest, lukewarm soaks or baths, bland emollients and oral antihistamines.2527, In patients with chronic idiopathic erythroderma, emollients and topical steroids may be effective. Although the etiology is. 1998;37(7):5203. 2010;85(2):131138. Still, treatment indication, choice and dosage remain unclear, and efficacy yet unproven. A recent review [111] on 33 pediatric cases of TEN and 6 cases of SJS/TEN overlap showed that therapy with IVIG with a dosage of 0.251.5g/kg for 5days resulted in 0% mortality rate and faster epithelization. Tohyama M, et al. Clinical clues of a drug-induced etiology include: Abrupt onset, previous morbilliform eruption, multiple, varied cutaneous morphologic lesions present together Extensive erythema is followed in 2-6 days by exfoliative scaling Pruritus can be severe, leading to scratching and lichenification in more chronic processes 2014;71(2):27883. The lesions consist of pruritic, annular papules, vesicles, and bullae that are found in groups, clinically it is similar to dermatitis herpetiformis, without a gluten-sensitive enteropathy [85]. Rheumatology (Oxford). 1997;22(3):1467. 2008;58(1):3340. Fournier S, et al. Detection of a herpes simplex viral antigen in skin lesions of erythema multiforme. 2011;20(2):10712. Initial symptoms could be aspecific, as fever, stinging eyes and discomfort upon swallowing, occurring few days before the onset of mucocutaneous involvement. 2013;69(4):37583. volume14, Articlenumber:9 (2016) The former is usually a recurring, localized eruption of the skin characterized by pathognomonic target or iris lesions, with minimal or no mucosal involvement (Fig. Etoricoxib-induced toxic epidermal necrolysis: successful treatment with infliximab. 2014;81(1):1521.